Antiretroviral Postexposure Prophylaxis After Sexual, Injection Drug Use, or Other Nonoccupational Exposure to HIV — CDC Recommendations, United States, 2025
These 2025 nonoccupational postexposure prophylaxis (nPEP) guidelines update recommendations and considerations for use of HIV nPEP in the United States to include newer antiretroviral (ARV) agents, updated nPEP indication considerations, and emerging nPEP implementation strategies. The guidelines also include considerations for testing and nPEP regimens for people exposed who have received long-acting injectable ARVs in the past. Lastly, testing recommendations for people who experienced sexual assault were updated to align with the most recent CDC sexually transmitted infection treatment guidelines.